To prepare this model, the researchers analyzed seven-year data from 1973 patients with type 1 diabetes in the EURODIAB prospective complication study, combining the prognostic factors of major complications with a computer model. The main complications of type 1 diabetes include: severe coronary heart disease, stroke, end-stage renal failure, amputation, blindness and all-cause mortality. Ninety-five patients with EURODIAB type 1 diabetes had major complications during follow-up. The prognostic factors for major complications were age, HbA1c, WHR, albumin/creatinine ratio, and HDL-(good) cholesterol.
The investigators were in three different prospective cohorts: Pittsburgh Diabetes Complications Epidemiology Study (EDC, USA, n=554), Finnish Diabetic Nephropathy Study (FinnDiane, Finland, n=2,999) and Type 1 Diabetes Study The coronary classification (CACTI, USA, n=580) examined the performance of the model. After correcting systematic differences between predictive and observational factors of some of the major complications in the cohort, the model can accurately predict patient risk. The authors stated: "The model can well distinguish between patients who exhibit major complications and patients who do not exhibit major complications. In the collection of the patient's age, glycated hemoglobin, waist-hip ratio, albumin-creatinine ratio and After HDL cholesterol information, health care professionals can enter this information into the provided score sheet, which will automatically calculate the 3, 5, and 7 year absolute risk of major complications in patients with type 1 diabetes."
They added: "Absolute risk prediction in patients with type 1 diabetes is very important for the timely detection of high-risk patients with severe complications to prevent the development of these complications and reduce medical costs. In addition, the predictive model for patients And selecting high-risk groups for randomized controlled trials (RCTs) has an important role."
The authors stress that this model can be used to help high-risk patients by dealing with all the changing risk factors. They said: "Predicting major complications allows us to establish risk analysis for patients with type 1 diabetes. Physicians may consider aggressive interventions in identified high-risk patients. These interventions include, in accordance with existing guidelines, intensive insulin. Treatment options and cardiovascular risk management More specifically, these results will help determine which patients are most at risk and thus help focus on interventions.Examples of such interventions include insulin, oral hypoglycemic agents, ACE inhibitors, and blood vessels. Angiotensin receptor blockers, statins, diet and lifestyle management."