Researchers from research institutes such as the Academy of Military Medical Sciences and the School of Life Sciences of Southwest University published the title "Mouse Embryonic Head as a Site for Hematopoietic Stem Cell Development", which confirmed for the first time that the embryonic head of mice is caused by hematopoietic stem cells (HSCs) A new location.
Researcher Xiao Yang and Bing Liu from the Academy of Military Medical Sciences are co-corresponding authors of this article. Researcher Yang Xiao is a leading figure in the field of gene knockout research in China. Because of its outstanding scientific research achievements, it has won the "China Youth Science and Technology Award", "China Young Female Scientist Award", "Qiushi Outstanding Young Practical Engineering Award", Japan JALAS International Award and other awards. And in 2006, he was selected as a national candidate for the New Century Talent Project.
Mammal hematopoiesis includes primitive hematopoiesis and permanent hematopoiesis, and permanent hematopoiesis is maintained by pluripotent hematopoietic stem cells. Hematopoietic stem cells are hematopoietic precursor cells with high self-renewal capacity and multi-directional differentiation potential, which can form blood cells of various blood lines, and can rebuild the hematopoietic system destroyed by lethal irradiation. The origin of hematopoietic stem cells has long been the focus of debate in the field of hematopoiesis. It used to be believed that it originated from the yolk sac outside the embryo. Some evidence in recent years indicates that hematopoietic stem cells originated from the aorta-gonad-mesonephros (AGM) region in the embryonic mesoderm.
In this article, the researchers confirmed that in addition to the AGM area, E10.5E11.5 mouse heads also have real HSCs. Before HSCs enter the embryo body cycle, they have long-term, high-level, multi-lineage reconstruction and self-renewal capabilities. The appearance and functional confirmation of intracellular vascular masses indicate that a classified endothelial cell group has hematopoietic capacity, indicating the presence of hematopoiesis in the head in the second trimester of pregnancy. In addition, the researchers confirmed the hematopoietic ability of the head endothelium by lineage tracking with an induced VE-cadherin-Cre transgene. Using a space-constrained lineage marking system, the researchers revealed the physiological contribution of cerebrovascular endothelium to postnatal HSCs and multi-lineage hematopoiesis.
The new paper confirms that the embryonic head is a new site where HSC occurs in a previously unknown developing embryo. Hematopoietic stem cells are the first group of stem cells to be used in clinical treatment. Because of their self-renewal, multi-directional differentiation, relatively wide sources, easy collection and in vitro processing, they have broad application prospects. Scientists have conducted in-depth research and attempts on its practical application in the treatment of blood diseases. However, in order to make better use of such highly potential stem cells, we must understand their origin more deeply. The new research indicates a new direction for a deeper study of the mechanism of hematopoietic stem cell development.
About the Author:
Yang Xiao
Researcher, doctoral tutor. Director of the Department of Developmental and Disease Genetics, Institute of Bioengineering, Academy of Military Medical Sciences. Winner of the National Outstanding Youth Fund. Engaged in molecular and developmental genetics research for 24 years. In recent years, based on China, we systematically studied the important physiological functions and molecular mechanisms of TGF-β / Smad and PTEN / Akt signaling pathways in the development and steady state maintenance of mammalian tissues and organs. He published 76 research papers and reviews (Developmental Cell, PNAS, EMBO J, Development and other SCI journals) (responsible author papers and 44 reviews). He cited more than 2,500 SCI papers. He has won the "China Youth Science and Technology Award", "China Young Female Scientist Award", "Qiu Shi Outstanding Youth Practical Engineering Award", Japan JALAS International Award. In 2006, he was selected as a national candidate for the New Century Talent Project.
Liu Bing
education:
1991.09-1996.06: Bachelor of Medicine, Clinical Medicine, Third Military Medical University;
1996.07-1999.06: Master of Medicine, Institute of Basic Medical Sciences, Academy of Military Medical Sciences;
1999.07-2002.06: Graduate School of the Second Military Medical University, Doctor of Medicine.
jobs:
2002.07-2004.09: Assistant Researcher, Institute of Basic Medical Sciences, Academy of Military Medical Sciences;
2004.09-2009.09: Associate Researcher, Institute of Basic Medical Sciences, Academy of Military Medical Sciences;
2005.05-2007.10: Deputy Director of Cell Biology Laboratory, Institute of Basic Medical Sciences, Academy of Military Medical Sciences;
2007.10-present: Director of the Oncology Research Office, 307 Hospital Affiliated to the Academy of Military Medical Sciences;
2009.09 to present: Researcher, 307 Hospital Affiliated to the Academy of Military Medical Sciences;
2010.02 to present: 307 Hospital Affiliated to the Academy of Military Medical Sciences, Director of 307-Qingto Translational Medicine Center.
Research interest:
1. Clarify the developmental relationship between blood vascular stem cells and directed hematopoietic stem cells;
2. Explore the in vivo molecular regulatory mechanism of blood-producing endothelial development (especially the specialization stage);
3. Establish a new method to evaluate the in vivo development kinetics of hematopoietic stem cell precursors;
4. Create embryonic stromal cell lines to support the differentiation of pluripotent stem cells to produce hematopoietic stem cells.
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