Liver progenitor cells can be used to treat end-stage liver disease


Researchers from the Mount Sinai School of Medicine in the United States have found that human embryonic stem cells can differentiate into a previously unknown liver progenitor cell, which is an early progeny of stem cells that produces mature functional hepatocytes. The findings point to the possibility that people may use cell therapy to regenerate the liver in patients with liver disease.

The researchers confirmed the functionality of hepatocytes produced by this progenitor cell because these hepatocytes can be infected with hepatitis C virus (HCV), in which HCV can only infect liver cells. A key finding of this study was the discovery that there is a receptor protein called KDR on the surface of this progenitor cell, or vascular endothelial growth factor receptor 2 (vascular endothelial growth factor receptor 2). Prior to this, it has been thought that this receptor is only present in endothelial cells that form blood vessels, namely endothelial progenitor cells and blood cell progenitor cells. The researchers confirmed that activation of KDRs on these new liver progenitors would allow them to differentiate into mature hepatocytes. In addition, studies on model mice have found similar cells, suggesting that this liver progenitor cells are conserved in mice and humans and therefore they must play an important role and are expected to be used in cell therapy for treatment. Liver disease.

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