Guide
It is well known that pancreatic cancer is the number one killer of cancer. The vast majority of patients die after one year of diagnosis, but still 7% of patients can survive for more than five years. A recent study by Tel Aviv University found this secret and designed a new nano-taxi to suppress pancreatic cancer.
The study was led by Professor Ronit Satchi-Fainaro, head of the Department of Physiology and Pharmacology at the TAU Sackler School of Medicine, co-chaired by Dr. Hadas Gibori and Dr. Shay Eliyahu. The findings were published in the journal Nature Communications.
According to Professor Ronit Satchi-Fainaro, if you can understand how these 7% of people survive, then you can develop new treatment strategies.
Calling nano "taxi"
The team tested pancreatic cancer cells and found a negative correlation between the tumor suppressor gene miR-34a and the oncogene PLK1. When the level of miR-34a is low in a mouse model of pancreatic cancer, the level of oncogene is high. This correlation is very meaningful for the treatment of malignant tumors.
But the research team needs to further confirm whether humans also have such a correlation. As a result, the researchers analyzed samples from patients with pancreatic cancer and found the same genomic pattern as in the mouse model of pancreatic cancer.
As a result, researchers have invented a new type of nanoparticle that selectively delivers genetic material to tumors and avoids side effects on surrounding healthy tissue.
Professor Satchi-Fainaro said, "We designed a nanocarrier to transport two "passengers": (1) miR-34a that degrades hundreds of oncogenes; (2) small interfering RNAs that silence individual genes of PLK1 ( siRNA) These are delivered directly to the tumor site to alter the molecular markers of the cancer cell, leaving the tumor in a dormant state or completely disappearing.
Professor Satchi-Fainaro went on to say that nanoparticles are like a "taxi" carrying two important passengers, keeping the "passengers" and other parts of the body safe, targeting only the tumor tissue. Once it is stopped, an enzyme present in pancreatic cancer causes the carrier to biodegrade, thereby releasing the therapeutic drug in the tumor cells.
Increase your chances of survival
To test this finding, the researchers injected the new nanoparticle into mice with pancreatic tumors and significantly prolonged the survival of mice by balancing these two goals.
According to Professor Satchi-Fainaro, this treatment takes into account the entire genome model and is expected to be the basis for the development of cocktails for this deadly disease and other cancers.
Shanghai Chuangsai Technology has excellent performance, interleukin cytokines, fetal bovine serum, electrophoresis equipment scientific instruments, raw material drug standards, chemical reagents, cell culture consumables, Shanghai Chuangsai, mass products special promotions, welcome to inquire!
MDF TOP round dining living room table wire base
This Dining Table is very popular and widely used in home, coffee shop and restaurant, you could match our home chair together.
We use environmental material and provide the perfect replica items.
The comfortable table is available in a selection of colours.
We also have many Home Accessories to decorate your home.
If you need more information, just feel free to contact me, I will send you more details pictures and information.
Living Room Tables,Indoor Living Room Tables,Modern Living Room Tables
Ningbo Realever Enterprise Limited , https://www.realeverfurnishing.com